December 1st 2013 will mark the 25th annual World AIDS Day with this year’s theme, “Shared Responsibility: Strengthening Results for an AIDS-Free Generation”. World AIDS Day provides an opportunity to spread awareness about the current status of the pandemic and to encourage progress in HIV/AIDS prevention, care and treatment around the world. According to the National AIDS Trust, approximately 25 million people have died from the HIV virus over the past 3 decades, making it one of the most devastating pandemics in history. However, in recent years there have been significant scientific advances in HIV treatment and education. A recent report by UN AIDS1 found that from 1995 to 2012 antiretroviral therapy (ARV) averted 6.6 million AIDS related deaths. This article focuses on progress against HIV among children and adolescents.